解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Growing evidence has uncovered that SLC34A2 plays an evident role in the progression in several types of tumors. However, the biological function and underlying molecular mechanisms of SLC34A2 remain largely unknown. Here, we indicated that SLC34A2 expression was markedly increased in SW480 and HT29 cell line cells co...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20180268
更新日期:2019-05-21 00:00:00
abstract::Neural stem cells (NSCs) transplantation is one of the most promising strategies for the treatment of CA-induced brain damage. The transplanted NSCs could differentiate into new neuron and replace the damaged one. However, the poor survival of NSCs in severe hypoxic condition is the limiting step to make the best use ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20181635
更新日期:2019-05-14 00:00:00
abstract::Radiotherapy is the primary treatment option for nasopharyngeal carcinoma (NPC). Local recurrence and metastasis caused by radioresistance become a bottleneck of curative effect for patients with NPC. Currently, serum predictive biomarkers of radioresistance are scare. We enrolled NPC patients, who underwent radiother...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20190027
更新日期:2019-05-14 00:00:00
abstract::Long non-coding RNAs (lncRNA) CASC2 is a key player in cancer biology. Our new findings showed that both lncRNA CASC2 and IL-17 were up-regulated in plasma of osteoarthritis patients. Plasma levels of lncRNA CASC2 and IL-17 were significantly and positive correlated only in osteoarthritis patients. Overexpression of l...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20182454
更新日期:2019-05-14 00:00:00
abstract::Intervertebral disc degeneration is a disease identified as an inflammation response-participated pathological process. As a classical cellular feature, disc cell senescence is reported to be closely related with disc cell senescence. Resveratrol has a protective role against inflammation in some cells. However, its b...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20190126
更新日期:2019-05-10 00:00:00
abstract::We assessed the relationship between the volume of epicardial adipose tissue and long-term outcomes in patients with coronary heart disease (CHD) undergoing percutaneous coronary intervention (PCI). The patients with CHD were followed for at least 2 years after PCI. The epicardial adipose tissue volume (EATV) was meas...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20182278
更新日期:2019-05-07 00:00:00
abstract::Prognostic significance of family with sequence similarity 83, member D (FAM83D) in hepatocellular carcinoma (HCC) patients has not been well-investigated using Gene Expression Omnibus (GEO) series and TCGA database, we compared FAM83D expression levels between tumor and adjacent tissues, and correlated FAM83D in tumo...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20181640
更新日期:2019-05-07 00:00:00
abstract::The extracts of Paulownia tomentosa (P. tomentosa) exhibit multiple pharmacological activities. In the present study, P. tomentosa flower polysaccharides (PTFP) were extracted by water decoction and ethanol precipitation, and the immunologic modulations of PTFP against Newcastle disease (ND) vaccine was investigated i...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20190224
更新日期:2019-05-03 00:00:00
abstract::Long non-coding RNA (lncRNA) H19 has been implicated in tumor angiogenesis. However, whether H19 regulates the progression of corneal neovascularization (CNV) is unclear. The present study aimed to determine the function of H19 in CNV and its possible molecular mechanism. Here, we found that the H19 levels were remark...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20182394
更新日期:2019-05-02 00:00:00
abstract::Ovarian cancer is a highly lethal cancer in females. Therefore, it is necessary to explore effective biomarkers for the diagnosis and prognosis of the disease. Stratifin (SFN) is a cell cycle checkpoint protein that has been reported to be involved in oncogenesis. Our studies detected the expression of SFN in ovarian ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20190100
更新日期:2019-05-02 00:00:00
abstract::Background: The present study aimed to evaluate serum 25-hydroxy vitamin D (25(OH) D) levels in Chinese patients with idiopathic benign paroxysmal positional vertigo (BPPV) and to investigate the possible relationship between the occurrence and recurrence of idiopathic BPPV and low 25(OH) D levels. Methods: Between 1 ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20190142
更新日期:2019-04-30 00:00:00
abstract::The growth arrest special 5 (GAS5), as a research hotspot of long noncoding RNAs (lncRNAs), has been reported to be associated with colorectal cancer (CRC). However, the association between polymorphisms in GAS5 and the risk of CRC was not clear. In the present study, a case-control study in 1078 CRC patients and 1175...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20190091
更新日期:2019-04-16 00:00:00
abstract::Ovarian cancer is one of the most common gynecological cancers with a high mortality rate in females. Chromatin target of protein arginine methyltransferase (CHTOP) is an important intracellular protein that regulates the transcriptional activation of several oncogenic genes in glioblastomagenesis and controls mature ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20190016
更新日期:2019-04-16 00:00:00
abstract::Baicalin is the main bioactive component extracted from the traditional Chinese medicine Baical Skullcap Root, and its anti-tumor activity has been studied in previous studies. PDZ-binding kinase/T-LAK cell-originated protein kinase (PBK/TOPK), a serine/threonine protein kinase, is highly expressed in many cancer cell...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20181692
更新日期:2019-04-09 00:00:00
abstract::The molecular mechanism of the occurrence and development of papillary thyroid carcinoma (PTC) has been widely explored, but has not been completely elucidated. The present study aimed to identify and analyze genes associated with PTC by bioinformatics methods. Two independent datasets were downloaded from Gene Expres...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20190083
更新日期:2019-04-02 00:00:00
abstract::Unstable angina pectoris (UA) is one of the most dangerous clinical symptoms of acute coronary syndrome due to the risk of myocardial ischemia, which can lead to high morbidity and mortality worldwide. Though there are many advantages in understanding the pathophysiology of UA, the identification of biomarkers for the...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20181658
更新日期:2019-03-22 00:00:00
abstract::Resistance to chemotherapy is one of main obstacles in the treatment of colorectal cancer (CRC). However, the mechanisms are still unclear, and the treatment options are still limited. miR-543 has been indicated to act as an oncogene in some cancers, but its function in regulating chemoresistance has not been consider...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20190249
更新日期:2019-03-22 00:00:00
abstract::Purpose: Wilson's disease (WD) is a genetic disorder of copper metabolism with pathological copper accumulation in the brain. The purpose of the present study was to evaluate the relationship between the damaged white matter and the impaired cognitive function in WD patients. Materials and methods: Thirty WD adolescen...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20181651
更新日期:2019-03-15 00:00:00
abstract:: Background/aims: Studies have demonstrated that osteopontin (OPN) was associated with the severity and development of knee osteoarthritis (OA). Methods: The purpose of this case-control study was to investigate the association ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20182023
更新日期:2019-02-27 00:00:00
abstract::Background: There is a clinical need for the use of engineered adipose tissue in place of surgical reconstruction. We previously found that the external volume expansion (EVE) device increased special cell clusters in well-vascularized connective stroma during adipose regeneration. However, the origin of these cell cl...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20181776
更新日期:2019-02-26 00:00:00
abstract:BACKGROUND:Annulus fibrosus (AF) is important to confine disc nucleus pulposus (NP) tissue during mechanical load experience. However, the knowledge on AF cell biology under mechanical load is much limited compared with disc NP. OBJECTIVE:The present study aimed to investigate responses of apoptosis and matrix metabol...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20182375
更新日期:2019-02-22 00:00:00
abstract::Understanding cell migration in a 3D microenvironment is essential as most cells encounter complex 3D extracellular matrix (ECM) in vivo Although interactions between cells and ECM have been studied previously on 2D surfaces, cell migration studies in 3D environment are still limited. To investigate cell migration und...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20181596
更新日期:2019-02-19 00:00:00
abstract::Having a better grasp of the molecular mechanisms underlying carcinogenesis and progression in osteosarcoma would be helpful to find novel therapeutic targets. Different types of cancers have presented abnormal expression of miRNA-101 (miR-101). Nevertheless, we still could not figure out what expression of miR-101 in...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20181283
更新日期:2019-02-08 00:00:00
abstract::Mice and rats are animals commonly used in research and laboratory testing. Compared with other animal species, they harbor many more zoonotic agents. Hymenolepis nana (H. nana) is a common tapeworm that parasitizes both humans and rodents. Although this tapeworm is of socio-economic importance worldwide, information ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20181224
更新日期:2019-02-08 00:00:00
abstract::Down-regulation of p16INK4a and miR-146b-5p contributes to tumorigenesis in osteosarcoma (OS). However, the correlation between p16INK4a and miR-146b-5p in OS proliferation remains largely unknown. In the present study, we demonstrated that miR-146b-5p expression was positively correlated with p16INK4a in OS, but inve...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20181268
更新日期:2019-02-01 00:00:00
abstract::Wilms tumor is the most common renal malignancy that occurs in children. TP53 gene is considered as a tumor-suppressing gene through controlling cell growth. TP53 gene rs1042522 C>G (Arg72Pro) polymorphism is widely investigated in various types of cancers. However, it is not established if TP53 rs1042522 C>G polymorp...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20181891
更新日期:2019-01-22 00:00:00
abstract::Neuroblastoma is the most common tumor in children, with a very poor prognosis. It is urgent to identify novel biomarkers to treat neuroblastoma, together with surgery, chemotherapy, and radiation. Human tripartite motif 59 (TRIM59), a member of the TRIM family, has been reported to participate in several human tumors...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20181277
更新日期:2019-01-18 00:00:00
abstract::Mycoplasma pneumoniae is one of the most common pathogenic causes of community-acquired pneumonia. Hydrogen sulfide, alanine, and pyruvate producing enzyme (HapE) is a recently discovered M. pneumoniae virulence factor that can produce H2S to promote erythrocyte lysis. However, other cytotoxic effects of HapE have not...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20182201
更新日期:2019-01-18 00:00:00
abstract::A consensus about the prognostic role of NIMA-related kinase 2 (NEK2) expression in various solid tumors has not been made yet. Thus, this meta-analysis aimed to systematically assess the prognostic role of NEK2 expression in patients with solid tumors. The eligible studies were identified through searching PubMed, We...
journal_title:Bioscience reports
pub_type: 杂志文章,meta分析
doi:10.1042/BSR20180618
更新日期:2019-01-18 00:00:00
abstract:BACKGROUND:This research aimed to study the associations between XPD (G751A, rs13181), hOGG1 (C326G, rs1052133) and XRCC4 (G1394T, rs6869366) gene polymorphisms and the risk of colorectal cancer (CRC) in a Chinese Han population. METHOD:A total of 225 Chinese Han patients with CRC were selected as the study group, and...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20181074
更新日期:2019-01-15 00:00:00
abstract::Some medicinal herbs and compounds are known to target cancer cells, but the success of them as anticancer compounds depends to a large extent on their ability to activate pathways that kill cancer cells by arresting cell cycle and inducing apoptosis. The aim of the present study was to determine the anticancer effect...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20181538
更新日期:2019-01-11 00:00:00
abstract::The tetracycline repressor (TetR)-regulated system is a widely used tool to study gene functions through control of its expression. Various effectors such as tetracycline (Tc) and doxycycline (Dox) quickly induce or shut down gene expression, but reversing gene expression has not been eligible due to long half-lives o...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20180793
更新日期:2019-01-08 00:00:00
abstract::We aimed to confirm the role of miR-1296-5p in gastric cancer and to identify its target genes. The expression of miR-1296-5p was measured in gastric cancer tissues and cell lines. The function of miR-1296-5p was examined by the overexpression and inhibition of its expression in typical gastric cell lines as well as S...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20181556
更新日期:2019-01-08 00:00:00
abstract::Type 2 diabetes mellitus (T2DM) complicated with non-alcoholic fatty liver disease (NAFLD) is difficult to treat. The present study explored the efficacy of (liraglutide) Lira in treating T2DM complicated with NAFLD. A total of 127 patients suffering from T2DM complicated with NAFLD were enrolled in the present study,...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20181304
更新日期:2018-12-21 00:00:00
abstract::Nonsmall cell lung cancer (NSCLC) is one of the most frequent malignancies worldwide. Long noncoding RNAs (LncRNAs) play critical roles in cancer initiation and progression. Previous studies have demonstrated that overexpression of cytoskeleton regulator RNA (CYTOR) predicates poor prognosis and promotes tumor progres...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20181599
更新日期:2018-12-18 00:00:00
abstract::Osteoarthritis (OA) is one of the most common chronic joint disease. Long non-coding RNAs (lncRNAs) have been confirmed to play important roles in a variety of diseases including OA. However, the underlying mechanism of lncRNA differentiation antagonizing non-protein coding RNA (DANCR) in OA has not been well elucidat...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20181228
更新日期:2018-12-14 00:00:00
abstract::Acquired resistance of afatinib is a significant challenge for non-small cell lung cancer (NSCLC) therapy and the mechanisms remain unclear. Aberrant activation of epidermal growth factor receptor (EGFR)-dependent downstream pathways, especially phosphatidylinositol-3-kinases/protein kinase B (PI3K/Akt) signaling path...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20181693
更新日期:2018-12-11 00:00:00
abstract::The association between dietary protein intake and ovarian cancer had been inconsistent in the previous epidemiological studies. The aim of the present study was to identify and synthesize all citations evaluating the relationship on ovarian cancer with protein intake. The search included PubMed, Embase, and Web of Sc...
journal_title:Bioscience reports
pub_type: 杂志文章,meta分析
doi:10.1042/BSR20181857
更新日期:2018-12-11 00:00:00
abstract::Background: Urotensin-II (UII) rs228648 polymorphism has been reported to be associated with the risk of diabetes mellitus (DM) with inconsistent results. The present study sought to reassess the relationship between this polymorphism and susceptibility to DM by meta-analysis.Methods: Relevant eligible studies and who...
journal_title:Bioscience reports
pub_type: 杂志文章,meta分析
doi:10.1042/BSR20181275
更新日期:2018-12-07 00:00:00
abstract::Human cytomegalovirus (HCMV) infection can cause inflammatory tissue-invasive end-organ diseases upon lytic replication. In humans, mature miR-200b-3p and -200c-3p suppress the synthesis of HCMV immediate early 2 (IE2) protein by binding to the 3'-UTR of the mRNA encoded by the unique long (UL) 122-123 region in human...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20180961
更新日期:2018-12-07 00:00:00